1H-Pyrrolo[2,3-c]pyridine, 3-(2-methyl-4-pyrimidinyl)-1-(phenylmethyl)-
AZ-Dyrk1B-33
CAS: 1679330-37-0
Molecular Formula: C19H16N4
1H-Pyrrolo[2,3-c]pyridine, 3-(2-methyl-4-pyrimidinyl)-1-(phenylmethyl)- - Names and Identifiers
1H-Pyrrolo[2,3-c]pyridine, 3-(2-methyl-4-pyrimidinyl)-1-(phenylmethyl)- - Physico-chemical Properties
| Molecular Formula | C19H16N4 |
| Molar Mass | 300.36 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Boling Point | 541.2±50.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 6.79±0.30(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC 50 of 0.192 μM. AZ-Dyrk1B-33 shows no effect in sensitization. |
1H-Pyrrolo[2,3-c]pyridine, 3-(2-methyl-4-pyrimidinyl)-1-(phenylmethyl)- - Reference Information
| biological activity | AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor with an IC50 value of 7 nM. |
| Target | IC50: 7 nM (Dyrk1B) |
Last Update：2024-04-09 19:05:17
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